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第一章 计算生物学课程介绍Chapter 1: Computational Biology: Introduction1.1 生物信息学、生物统计学与计算结构生物学的定义What is bioinformatics, biostatistics and computational structural biology (CSB)1.2 生物信息学、生物统计学与计算结构生物学的概念和发展历史Concept and history of bioinformatics, biostatistics and CSB第一部分 生物信息学Section 1: Bioinformatics本节系统介绍当前生物信息学领域中各个层面的研究内容，主要包括生物序列分析、生物大分子结构模拟与分析、基因和蛋白表达分析、基因和蛋白表达调控分析等内容，涵盖了符合当前分子生物学领域最新发展动向的所有计算手段和方法。This section will introduce the basic ideas and the advanced computational methods in the field of molecular biology, which aims at providing the requisite algorithms for biological sequence analysis, macromolecular structural simulation and analysis, gene and protein expression analysis and regulatory analysis as well. Prerequisites include a basic understanding of protein and nucleic acid structure, and some mathematics and statistics, but no prior knowledge of computer programming is necessary.第二章 序列比对Chapter 2: Pairwise Sequence Alignment and Multiple Sequence Alignment第三章 基因预测与基因组注释Chapter 3: Gene Prediction and Genome Annotation第四章 转录组数据分析Chapter 4: Tranomic Data Analysis第五章 系统发生分析Chapter 5: Phylogenic Analysis第六章 分子网络Chapter 6: Molecular Network Analysis第七章 元基因组学Chapter 7: Metagenomics第八章 系统生物学Chapter 8: Systems Biology第二部分 生物统计学Section 2: Biostatistics本节内容采用案例教学的方法，根据教学对象的特点，针对性的介绍了与临床试验和分子生物学密切相关的统计学方法，囊括描述性统计、推断性统计、试验设计等内容。This section introduces the statistics concepts and methods with emphasis on the applications in the field of clinical trial, and molecular biology, which will cover the deive statistics, inferential statistics and experimental design.第九章 生物统计学研究前沿Chapter 9: Recent progress第十章 总体与样本Chapter 10: Populations and Samples第十一章 描述性统计Chapter 11: Deive Statistics第十二章 参数型与非参数型检验Chapter 12: Parametric Test and Non-parametric Test第十三章 相关与回归分析Chapter 13: Correlation and Regression Analysis第十四章 试验设计Chapter 14: Experiment/Study Design第十五章 应用组学统计学Chapter 15: Omicis Statistics第三部分 计算结构生物学Section 3: Computational Structural Biology第十六章 蛋白二级结构Chapter 16: Protein Secondary Structure第十七章 蛋白三级结构Chapter 17: Protein tertiary Structure第十八章 小分子模拟Chapter 18: Small-molecular Simulation第十九章 分子对接Chapter 19: Molecular Docking第二十章 酶反应Chapter 20: Enzymatic Reaction第廿一章 基于结构的药物设计Chapter 21: Structure-based Drug Design第廿二章 RNA和DNA折叠Chapter 22: RNA and DNA Folding第廿三章 课程讲座Chapter 23: Open Lecture
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